Dr. Anubama Rajan Papers

  1. Rajan A, Nagaraj D, Bomidi C, Aloisio GM, Murray AM, Schultz EM, Kambal A, Estes MK, Nicholson E, Avadhanula V, Blutt SE, Piedra PA. Single cell sequencing analysis of respiratory syncytial virus-infected pediatric and adult human nose organoids reveals age differences, proliferative diversity and identifies novel cellular tropism. J Infect. 2025 Sep 18;91(4):106617. doi: 10.1016/j.jinf.2025.106617. Epub ahead of print. PMID: 40975328.
  2. Avadhanula, V., Creighton, C. J., Ferlic-Stark, L., Nagaraj, D., Zhang, Y., Sucgang, R., Nicholson, E. G., Rajan, A., Menon, V. K., Doddapaneni, H., Muzny, D. M., Metcalf, G. A., Cregeen, S. J. J., Hoffman, K. L., Gibbs, R. A., Petrosino, J. F., & Piedra, P. A. (2025). Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load. PloS One, 20(1), e0317033. https://doi.org/10.1371/journal.pone.0317033
  3. Martins, F. H., Rosay, T., Rajan, A., Carter, H. E., Turocy, T., Mejia, A., Crawford, J. M., Maresso, A. W., & Sperandio, V. (2024). Enterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence. Nature Microbiology, 9(9), 2448–2461. https://doi.org/10.1038/s41564-024-01747-1
  4. Boyd, A. I., Kafer, L. A., Escapa, I. F., Kambal, A., Tariq, H., Hilsenbeck, S. G., Nguyen-Phuc, H., Rajan, A., Lensmire, J. M., Patras, K. A., Piedra, P. A., Blutt, S. E., & Lemon, K. P. (2024). Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids. BioRxiv. https://doi.org/10.1101/2024.09.25.614934
  5. Aloisio, G. M., Nagaraj, D., Murray, A. M., Schultz, E. M., McBride, T., Aideyan, L., Nicholson, E. G., Henke, D., Ferlic-Stark, L., Rajan, A., Kambal, A., Johnson, H. L., Mosa, E., Stossi, F., Blutt, S. E., Piedra, P. A., & Avadhanula, V. (2024). Infant-derived human nasal organoids exhibit relatively increased susceptibility, epithelial responses, and cytotoxicity during RSV infection. The Journal of Infection, 89(6), 106305. https://doi.org/10.1016/j.jinf.2024.106305
  6. Avadhanula, V., Creighton, C., Ferlic-Stark, L., Sucgang, R., Zhang, Y., Nagaraj, D., Nicholson, E., Rajan, A., Menon, V., Doddapaneni, H., Muzny, D., Metcalf, G., Cregeen, S. J., Hoffman, K., Gibbs, R., Petrosino, J., & Piedra, P. (2023). Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load. Research Square. https://doi.org/10.21203/rs.3.rs-2978272/v1
  7. Carter, H., Clark, J., Carlin, L. G., Vaughan, E., Rajan, A., Olvera, A., Yu, X., Zeng, X.-L., Kambal, A., Holder, M., Qin, X., Gibbs, R. A., Petrosino, J. F., Muzny, D. M., Doddapaneni, H., Menon, V. K., Hoffman, K. L., Meng, Q., Ross, M. C., … Okhuysen, P. C. (2023). Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea. BioRxiv. https://doi.org/10.1101/2023.05.31.543115
  8. Rajan, A., Weaver, A. M., Aloisio, G. M., Jelinski, J., Johnson, H. L., Venable, S. F., McBride, T., Aideyan, L., Piedra, F. A., Ye, X., Melicoff-Portillo, E., Yerramilli, M. R. K., Zeng, X. L., Mancini, M. A., Stossi, F., Maresso, A. W., Kotkar, S. A., Estes, M. K., Blutt, S., … Piedra, P. A. (2022). The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics. MBio, 13(1). https://doi.org/10.1128/MBIO.03511-21
  9. Rajan, A., Piedra, F.-A., Aideyan, L., McBride, T., Robertson, M., Johnson, H. L., Aloisio, G. M., Henke, D., Coarfa, C., Stossi, F., Menon, V. K., Doddapaneni, H., Muzny, D. M., Javornik Cregeen, S. J., Hoffman, K. L., Petrosino, J., Gibbs, R. A., Avadhanula, V., & Piedra, P. A. (2022). Multiple Respiratory Syncytial Virus (RSV) Strains Infecting HEp-2 and A549 Cells Reveal Cell Line-Dependent Differences in Resistance to RSV Infection. Journal of Virology, 96(7). https://doi.org/10.1128/jvi.01904-21
  10. Piedra, F.-A., Henke, D., Rajan, A., Muzny, D. M., Doddapaneni, H., Menon, V. K., Hoffman, K. L., Ross, M. C., Javornik Cregeen, S. J., Metcalf, G., Gibbs, R. A., Petrosino, J. F., Avadhanula, V., & Piedra, P. A. (2022). Modeling nonsegmented negative-strand RNA virus (NNSV) transcription with ejective polymerase collisions and biased diffusion. Frontiers in Molecular Biosciences, 9, 1095193. https://doi.org/10.3389/fmolb.2022.1095193
  11. Martins, F. H., Rajan, A., Carter, H. E., Baniasadi, H. R., Maresso, A. W., & Sperandio, V. (2022). Interactions between Enterohemorrhagic Escherichia coli (EHEC) and Gut Commensals at the Interface of Human Colonoids. MBio, 13(3). https://doi.org/10.1128/mbio.01321-22
  12. Ye, X., Angelo, L. S., Nicholson, E. G., Iwuchukwu, O. P., Cabral de Rezende, W., Rajan, A., Aideyan, L. O., McBride, T. J., Bond, N., Santarcangelo, P., Rayford, Y. J., Ferlic-Stark, L., Fragoso, S., Momin, Z., Liu, H., Truong, K., Lopez, B., Conner, M. E., Rice, A. P., … Piedra, P. A. (2021). Serum IgG anti-SARS-CoV-2 Binding Antibody Level Is Strongly Associated With IgA and Functional Antibody Levels in Adults Infected With SARS-CoV-2. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.693462
  13. Olvera, A., Carter, H., Rajan, A., Carlin, L. G., Yu, X., Zeng, X. L., Shelburne, S., Bhatti, M., Blutt, S. E., Shroyer, N. F., Jenq, R., Estes, M. K., Maresso, A., & Okhuysen, P. C. (2021). Enteropathogenic Escherichia coli Infection in Cancer and Immunosuppressed Patients. Clinical Infectious Diseases, 72(10), E620–E629. https://doi.org/10.1093/cid/ciaa1394
  14. Wilson, R. L., Hewes, S. A., Rajan, A., Lin, S. C., Bomidi, C., Iida, T., Estes, M. K., Maresso, A. W., & Grande-Allen, K. J. (2021). A Millifluidic Perfusion Cassette for Studying the Pathogenesis of Enteric Infections Using Ex-Vivo Organoids. Annals of Biomedical Engineering, 49(4), 1233–1244. https://doi.org/10.1007/s10439-020-02705-8
  15. Swaminathan, G., Kamyabi, N., Carter, H. E., Rajan, A., Karandikar, U., Criss, Z. K., Shroyer, N. F., Robertson, M. J., Coarfa, C., Huang, C., Shannon, T. E., Tadros, M., Estes, M. K., Maresso, A. W., & Grande-Allen, K. J. (2021). Effect of substrate stiffness on human intestinal enteroids’ infectivity by enteroaggregative Escherichia coli. Acta Biomaterialia, 132, 245–259. https://doi.org/10.1016/j.actbio.2021.07.024
  16. Green, S. I., Liu, C. G., Yu, X., Gibson, S., Salmen, W., Rajan, A., Carter, H. E., Clark, J. R., Song, X., Ramig, R. F., Trautner, B. W., Kaplan, H. B., & Maresso, A. W. (2021). Targeting of mammalian glycans enhances phage predation in the gastrointestinal tract. MBio, 12(1), 1–18. https://doi.org/10.1128/mBio.03474-20
  17. Doddapaneni, H., Cregeen, S. J., Sucgang, R., Meng, Q., Qin, X., Avadhanula, V., Chao, H., Menon, V., Nicholson, E., Henke, D., Piedra, F. A., Rajan, A., Momin, Z., Kottapalli, K., Hoffman, K. L., Sedlazeck, F. J., Metcalf, G., Piedra, P. A., Muzny, D. M., … Gibbs, R. A. (2021). Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals. PLoS ONE, 16(8). https://doi.org/10.1371/journal.pone.0244468
  18. Criss, Z. K., Bhasin, N., Di Rienzi, S. C., Rajan, A., Deans-Fielder, K., Swaminathan, G., Kamyabi, N., Zeng, X. L., Doddapaneni, H., Menon, V. K., Chakravarti, D., Estrella, C., Yu, X., Pati, K., Petrosino, J. F., Fleet, J. C., Verzi, M. P., Christakos, S., Helmrath, M. A., … Shroyer, N. F. (2021). Drivers of transcriptional variance in human intestinal epithelial organoids. Physiological Genomics, 53(11), 486–508. https://doi.org/10.1152/physiolgenomics.00061.2021
  19. Rajan, A., Robertson, M. J., Carter, H. E., Poole, N. M., Clark, J. R., Green, S. I., Criss, Z. K., Zhao, B., Karandikar, U., Xing, Y., Margalef-Català, M., Jain, N., Wilson, R. L., Bai, F., Hyser, J. M., Petrosino, J., Shroyer, N. F., Blutt, S. E., Coarfa, C., … Maresso, A. W. (2020). Enteroaggregative E. coli adherence to human heparan sulfate proteoglycans drives segment and host-specific responses to infection. PLoS Pathogens, 16(9). https://doi.org/10.1371/journal.ppat.1008851
  20. Koestler, B. J., Ward, C. M., Fisher, C. R., Rajan, A., Maresso, A. W., & Payne, S. M. (2019). Human intestinal enteroids as a model system of shigella pathogenesis. Infection and Immunity, 87(4). https://doi.org/10.1128/IAI.00733-18
  21. Rajan, A., Vela, L., Zeng, X. L., Yu, X., Shroyer, N., Blutt, S. E., Poole, N. M., Carlin, L. G., Nataro, J. P., Estes, M. K., Okhuysen, P. C., & Maresso, A. W. (2018). Novel segment- and host-specific patterns of enteroaggregative escherichia coli adherence to human intestinal enteroids. MBio, 9(1). https://doi.org/10.1128/mBio.02419-17
  22. Poole, N. M., Green, S. I., Rajan, A., Vela, L. E., Zeng, X. L., Estes, M. K., & Maresso, A. W. (2017). Role for FimH in extraintestinal pathogenic Escherichia coli invasion and translocation through the intestinal epithelium. Infection and Immunity, 85(11). https://doi.org/10.1128/IAI.00581-17
  23. Poole, N. M., Rajan, A., & Maresso, A. W. (2018). Human Intestinal Enteroids for the Study of Bacterial Adherence, Invasion, and Translocation. Current Protocols in Microbiology, 50(1). https://doi.org/10.1002/cpmc.55
  24. Rajan, A., Shi, H., & Xue, B. (2018). Class I and II Histone Deacetylase Inhibitors Differentially Regulate Thermogenic Gene Expression in Brown Adipocytes. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-31560-w
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